The best defense is not a good offense. It's this.
(Heroes in room): Defense +100/+150
(Mobs in room): Dust loot probability -40%/-30%
This skill massively increase the team's survivability against enemies in a single room. Reduced dust gain is bad, especially compared to Dust Thirst, because this skill applies that to all enemies in the room, instead of just a single enemy like Dust Thirst.